Bioassay

oaPHARMACOLOGY Principles and Methods of hindrance Prof. Ramesh K. Goyal L. M. College of Pharmacy Navrangpura Ahmedabad- 380 009 (18.01.2008) CONTENTS luster of bio-assay Principle of bio-assay Methods of Bioassay for Agonists Bioassay of Antagonists Bioassay of some important medicates consummation status of Bioassay in different Pharmacopoeia Other statuesque Bioassays Keywords Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase,diphtheria vaccine, elicit vaccine 1 Bioassay is defined as the estimation of the potency of an vigorous dogma in a unit quantity of education or detection and gait of the concentration of the substance in a preparation use biological methods (i.e. observation of pharmacological effects on compensate tissues, microorganisms or immune cells or animal). Hence micro assay, radioimmunoassay are also regarded as ` assay. of late `biotechnology has also been considered for bio-assay. Bioassay of the products care well erythropoietin, hepatitisB vaccine etcetera is being done through with(predicate) biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g.

chemical substance or tangible assay) are little accurate, less elaborate, much laborious, more troublesome and more expensive. However, bioassay is the only method of assay if (1) active voice principle of do drugs is unknown or can non be isolated, e.g. insulin, fanny pituitary extract etc. (2) Chemical method is both non available or if available, it is too complex and refractory or requires higher window pane e.g. insulin, acetylcholine. (3) Chemical composition is not known, e.g. long acting thyroid stimulants. (4) Chemical composition of drug differs but have the homogeneous pharmacological action and vice-versa, e.g. cardiac glycosides, catecholamines etc. Moreover, even if chemical methods are available and the results of bioassay conflict with those of the chemical assay,...If you wishing to get a spacious essay, order it on our website: Orderessay

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